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Fully Functional Hair Follicle Regeneration Through The Rearrangement Of Stem Cells And Their Niches

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Research group headed by Professor Takashi Tsuji demonstrates regenerating “functional hair regeneration from adult stem cells” Substantial advance in the development of next-generation of “organ replacement regenerative therapies”


Organ replacement regenerative therapy is purported to enable the replacement of organs damaged by disease, injury or aging in the foreseeable future. Here we demonstrate fully functional hair organ regeneration via the intracutaneous transplantation of a bioengineered pelage and vibrissa follicle germ.


The pelage and vibrissae are reconstituted with embryonic skin-derived cells and adult vibrissa stem cell region-derived cells, respectively.




The bioengineered hair follicle develops the correct structures and forms proper connections with surrounding host tissues such as the epidermis, arrector pili muscle and nerve fibres. The bioengineered follicles also show restored hair cycles and piloerection through the rearrangement of follicular stem cells and their niches.


This study thus reveals the potential applications of adult tissue-derived follicular stem cells as a bioengineered organ replacement therapy.


Organ replacement regenerative therapy is expected to provide novel therapeutic systems for donor organ transplantation, which is an approach to treating patients who experience organ dysfunction as the result of disease, injury or aging. Concepts in current regenerative therapy include stem cell transplantation and two-dimensional uniform cell sheet technologies, both of which have the potential to restore partially lost tissue or organ function.


The development of bioengineered ectodermal organs, such as teeth, salivary glands, or hair follicles may be achieved by reproducing the developmental processes that occur during organogenesis. Ectodermal organs have essential physiological roles and can greatly influence the quality of life by preventing the morbidity associated with afflictions such as caries and hypodontia in teeth10, hyposalivation in the salivary gland, and androgenetic alopecia, which affects the hair.


Recently, it has been proposed that a bioengineered tooth can restore oral and physiological function through the transplantation of bioengineered tooth germ and a bioengineered mature tooth unit, which would represent a successful organ-replacement regenerative therapy.


The hair coat has important roles in thermoregulation, physical insulation, sensitivity to noxious stimuli, and social communication. In the developing embryo, hair follicle morphogenesis is regulated by reciprocal epithelial and mesenchymal interactions that occur in almost all organs.


Complete hair loss article

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