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munkychunks

Finastride Q

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Hello,

 

Would anyone happen to know if Finastride makes you infertile? I have looked on the Propecia website and this is not a side effect but I may possible want a family in the future and I would like know if this has any effect on reproduction? I.e. Could it cause any defects / deformaties with unborn babies? Thanks

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Hi Munkychunks

 

I was on proscar/fin for a year and my bird gave birth to a healthy baby boy 2 years ago.He looks like me so i`m sure the fin had no effects on me.

 

Spexs wife also had twins recently and he has been on meds for years.

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it's advised that if you cut Fin tablets up, you should be careful not to expose women of child bearing age to any crumbs or bits of the pill, as it can possibly have an effect on the baby's development.

 

Whether this can pass through semen, I think is debated. You might have to get an expert's opinion to be sure if you want to have kids

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it's advised that if you cut Fin tablets up, you should be careful not to expose women of child bearing age to any crumbs or bits of the pill, as it can possibly have an effect on the baby's development.

 

Whether this can pass through semen, I think is debated. You might have to get an expert's opinion to be sure if you want to have kids

 

Hi Joe, from the drug information at the Electronic Medicines Compendium (http://emc.medicines.org.uk/)

 

Exposure to finasteride: risk to male foetus

 

A small amount of finasteride, less than 0.001% of the 1 mg dose per ejaculation, has been detected in the seminal fluid of men taking 'Propecia'. Studies in Rhesus monkeys have indicated that this amount is unlikely to constitute a risk to the developing male foetus (see Section 5.3).

 

During continual collection of adverse experiences, post-marketing reports of exposure to finasteride during pregnancy via semen of men taking 1 mg or higher doses have been received for eight live male births, and one retrospectively-reported case concerned an infant with simple hypospadias. Causality cannot be assessed on the basis of this single retrospective report and hypospadias is a relatively common congenital anomaly with an incidence ranging from 0.8 to 8 per 1000 live male births. In addition, a further nine live male births occurred during clinical trials following exposure to finasteride via semen, during pregnancy, and no congenital anomalies have been reported.

 

Crushed or broken tablets of 'Propecia' should not be handled by women when they are or may potentially be pregnant because of the possibility of absorption of finasteride and the subsequent potential risk to a male foetus. 'Propecia' tablets are coated to prevent contact with the active ingredient during normal handling, provided that the tablets are not broken or crushed.

 

5.3 Preclinical safety data

 

5.3 Preclinical safety data

 

In general, the findings in laboratory animal studies with oral finasteride were related to the pharmacological effects of 5α-reductase inhibition.

 

Intravenous administration of finasteride to pregnant rhesus monkeys at doses as high as 800 ng/day during the entire period of embryonic and foetal development resulted in no abnormalities in male foetuses. This represents at least 750 times the highest estimated exposure of pregnant women to finasteride from semen. In confirmation of the relevance of the Rhesus model for human foetal development, oral administration of finasteride 2 mg/kg/day (100 times the recommended human dose or approximately 12 million times the highest estimated exposure to finasteride from semen) to pregnant monkeys resulted in external genital abnormalities in male foetuses. No other abnormalities were observed in male foetuses and no finasteride-related abnormalities were observed in female foetuses at any dose.

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interesting.... so that data suggests that the risk of transfering Fin through semen is minimal/non-existant?

 

 

I'm glad this topic was brought up because I wanted to ask you something, Pondle:

 

I'm very careful when I cut the Fin pills up and store the segments in a sealed container, but I'm still concerned that specks or crumbs may be around when I have female friends/family round my house.

 

What I wanted to know is, in the unlikely event that some Fin did accidently enter a girl/woman's body, would it be excreted after a short while? In other words, it wouldn't remain in her body for a long time/forever? And thus would pose no risk to any foetus, as long as she isn't currently pregnant or has no plans to be in the near future.

 

 

Cheers,

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interesting.... so that data suggests that the risk of transfering Fin through semen is minimal/non-existant?

 

Yep.

 

I'm very careful when I cut the Fin pills up and store the segments in a sealed container, but I'm still concerned that specks or crumbs may be around when I have female friends/family round my house.

 

You should try to store your medicines safely and securely. Most people seem to manage OK, but if you're really concerned about crumbs, get Propecia rather than Proscar so you won't have to cut the tablets.

 

What I wanted to know is, in the unlikely event that some Fin did accidently enter a girl/woman's body, would it be excreted after a short while? In other words, it wouldn't remain in her body for a long time/forever? And thus would pose no risk to any foetus, as long as she isn't currently pregnant or has no plans to be in the near future.

 

Well if she isn't pregnant, there's no risk to a non-existent foetus! ;)

 

Finasteride is metabolised in the liver and has a half-life of 5-6 hours, so it is eliminated from the body relatively quickly. Whether a single dose would be capable of deforming a male foetus, I really don't know - you'd have to ask a specialist doctor or pharmacist.

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yeah I thought it was unlikely but I just wanted to be cautious.

 

I read somewhere that if a woman ingested Fin then any baby she had in the future would be affected, but I figured it was just hyperbole and scaremongering.

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